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PICRUSt2 analysis showed that the changes in gut microbiota induced by adzuki bean supplementation may be associated with the metabolism of carbohydrates, lipids, sulfur, and cysteine and methionine and LPS biosynthesis and valine, leucine, and isoleucine degradation.Īt present, public health is threatened by the increasing occurrence of obesity worldwide.

Adzuki bean significantly reduced the ratio of Firmicutes/ Bacteroidetes ( F/ B) enriched the occurrence of Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, and Lachnoclostridium and returned HFD-dependent taxa ( Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, and Ruminiclostridium) back to normal status. In addition, it significantly reversed HFD-induced gut microbiota imbalances. In particular, adzuki bean supplementation improved glucose homeostasis by increasing insulin sensitivity. It also mitigated liver function damage and hepatic steatosis. Adzuki bean supplementation significantly reduced obesity, lipid accumulation, and serum lipid and lipopolysaccharide (LPS) levels induced by HFD. Mice were fed a low-fat diet, a HFD, and a HFD supplemented with 15% adzuki bean (HFD-AB) for 12 weeks.

Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied.

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